Metabolic Health & Obesity
"Insulin Resistance, Leptin Sensitivity & Adipose Inflammation"
Weight loss resistance is rarely a matter of willpower. It stems from chronic hyperinsulinemia, mitochondrial sluggishness, thyroid conversion blocks, and adipose tissue inflammation.
From Lisa Cutforth — Clinical Nutritionist
"When we fix insulin sensitivity and cellular energy production, the body naturally shifts from storing fat to burning fuel."
Lisa Cutforth
BSc. Hons. (Nutrition & Psychology) · Walsh Protocol Practitioner
Cellular Pathways
Biochemical Mechanism & Systems Interplay
The body does not operate in silos. Here is the biochemical reality of how nutrient cofactors govern metabolic health & obesity.
Sustained elevated insulin locks adipocytes in lipogenesis and inhibits hormone-sensitive lipase. Inflammatory cytokines (TNF-a) impair insulin receptor substrate (IRS-1) signaling.
"When we correct enzymatic blocks with bio-available cofactors, physiology realigns naturally."
Standard blood ranges are designed to detect acute disease. We look for optimal functional biochemistry.
- Fasting Insulin & HOMA-IR
- HbA1c & Continuous Glucose Profile
- High-Sensitivity C-Reactive Protein (hs-CRP)
- Leptin & Adiponectin Ratio
Therapeutic Nutrition
Where Nutrition Enters Metabolic Health
Nutrients act as chemical keys for the enzymatic locks controlling your physiological state.
Berberine & Alpha Lipoic Acid (ALA)
Prescribed based on strict individual biochemistry, therapeutic dosing windows, and cofactor synergy.
Chromium Picolinate & Myo-Inositol
Prescribed based on strict individual biochemistry, therapeutic dosing windows, and cofactor synergy.
CoQ10 & Acetyl-L-Carnitine
Prescribed based on strict individual biochemistry, therapeutic dosing windows, and cofactor synergy.
Polyphenols & Fibre Complexes
Prescribed based on strict individual biochemistry, therapeutic dosing windows, and cofactor synergy.
Expert Understanding
Frequently Asked Clinical Questions
Explore The Web
Connected Health Pillars
Women's Health & Hormones
Hormone synthesis, follicle maturation, and endometrial cycling require precise nutritional inputs across all 28 days. From heavy menstrual bleeding to perimenopausal transition, targeted nutrition balances oestrogen detoxification, luteal progesterone support, and thyroid interactions.
Gut-Brain Axis & Microbiome
Over 90% of the body's serotonin and a significant portion of GABA are generated in the gastrointestinal tract. Intestinal dysbiosis and leaky gut directly trigger neuroinflammation through bacterial lipopolysaccharides (LPS).
Adrenal & Stress Physiology
Chronic stress alters the hypothalamic-pituitary-adrenal (HPA) axis, depleting vital cofactors required for cortisol synthesis, catecholamine regulation, and thyroid activation.
Restore Your Biology with Precision
Ready to resolve your symptoms at the genetic and biochemical root? Lisa Cutforth provides bespoke, confidential consultations in Brisbane and via Telehealth Australia-wide.